Article Text

Download PDFPDF
Pre-eclampsia as an etiology for preterm birth: what is the burden of disease for twins?
  1. SA Vogel1,
  2. AJ Kane1,
  3. R Rajaii2,
  4. Y Cheng1,
  5. AB Caughey1
  1. 1University of California, San Francisco, USA
  2. 2University of California, Berkeley, USA


Objective The authors evaluated the differences in twin preterm birth rates in the setting of pre-eclampsia by gestational age at birth and between different racial/ethnic groups.

Abstract PM.50
Abstract PM.50

Study Design This is a retrospective cohort study of women pregnant with twins delivered in California in 2006, separated into two cohorts: pre-eclampsia and no pre-eclampsia. Outcome data were tabulated by four gestational age groups (24–27, 28–31, 32–36 and 37–42 weeks) and stratified by race/ethnicity.

Results Women with pre-eclampsia are at a significantly increased risk of delivering at 32–36 weeks as compared to women without pre-eclampsia (p<0.001): 61.4% vs 45.5%. Preterm delivery rates in the setting of pre-eclampsia varied by race/ethnicity and were significantly higher in Caucasians and lower in Asians (p<0.001): 71.0% in Caucasians, 66.7% in African Americans, 67.0% in Latinas and 63.6% in Asians.

Conclusion Women with twins who also have pre-eclampsia have 15.9% more preterm births. Although African American women without pre-eclampsia experience higher preterm birth rates than other racial/ethnic groups, this effect is not seen in African American women with pre-eclampsia. In the setting of pre-eclampsia, Caucasians have more and Asians have fewer preterm births than other racial/ethnic groups.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.