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The role of androgens in fetal growth: observational study in two genetic models of disordered androgen signalling
  1. Harriet L Miles1,
  2. Sebastian Gidlöf2,
  3. Anna Nordenström2,
  4. Ken K Ong1,3,
  5. Ieuan A Hughes1
  1. 1Department of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK
  2. 2Division of Pediatrics, Department of Clinical Science, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden
  3. 3MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK
  1. Correspondence to Professor Ieuan A Hughes, Department of Paediatrics, University of Cambridge, Box 116, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK; iah1000{at}


Objective To examine the role of androgens on birth weight in genetic models of altered androgen signalling.

Setting Cambridge Disorders of Sex Development (DSD) database and the Swedish national screening programme for congenital adrenal hyperplasia (CAH).

Patients (1) 29 girls with XY karyotype and mutation positive complete androgen insensitivity syndrome (CAIS); (2) 43 girls and 30 boys with genotype confirmed CAH.

Main outcome measures Birth weight, birth weight-for-gestational-age (birth weight standard deviation score (SDS)) calculated by comparison with national references.

Results Mean birth weight SDS in CAIS XY infants was higher than the reference for girls (mean, 95% CI: 0.4, 0.1 to 0.7; p=0.02) and was similar to the national reference for boys (0.1, −0.2 to 0.4). Birth weight SDS in CAH girls was similar to the national reference for girls (0.0, −0.2 to 0.2) and did not vary by severity of gene mutation. Birth weight SDS in CAH boys was also similar to the national reference for boys (0.2, −0.2 to 0.6).

Conclusion CAIS XY infants have a birth weight distribution similar to normal male infants and birth weight is not increased in infants with CAH. Alterations in androgen signalling have little impact on birth weight. Sex dimorphism in birth size is unrelated to prenatal androgen exposure.

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  • Funding Support for the study was received from EC Framework 7, BDF Newlife, the Mothercare Foundation and the NIHR Biomedical Research Centre in Cambridge. The CAH work was supported by Sällskapet Barnavård, Stiftelsen Samariten, the Stiftelsen Frimurare Barnhuset and the Sven Jerring Foundation.

  • Competing interests None.

  • Ethics approval Ethics approval for this study was granted by Cambridgeshire Ethics 2 and the Karolinska ethics committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.