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Efficacy of prophylactic intravenous calcium administration in first 5 days of life in high risk neonates to prevent early onset neonatal hypocalcaemia: a randomised controlled trial
  1. Mohd Asif Ghufran Khan,
  2. Amit Upadhyay,
  3. Somashekhar Chikanna,
  4. Vijay Jaiswal
  1. Department of Pediatrics, LLRM Medical College, Meerut, Uttar Pradesh, India
  1. Correspondence to Dr Amit Upadhyay, Department of Pediatrics, LLRM Medical College, Garh Road, Meerut 250004, UP, India; anuamit7{at}

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Early onset neonatal hypocalcaemia (ENH) is defined as low serum calcium in first 3–5 days of life. As it is a common problem in premature babies, those with birth asphyxia and infants of diabetic mothers, prophylactic intravenous calcium infusion (IVCI) is recommended in high risk newborns.1 However, there is no consensus regarding the use of IVCI in neonatal intensive care units to prevent ENH.2 3

IVCI has some side effects.4 Intravenous calcium is known to cause tissue necrosis if it extravasates, which can lead to medicolegal problems. Therefore, we decided to evaluate the efficacy of continuous prophylactic …

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  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the Ethics Committee Review Board, LLRM Medical College, Meerut, UP, India.

  • Provenance and peer review Not commissioned; externally peer reviewed.