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Bilateral retinoblastoma presenting at retinopathy of prematurity screening
  1. J Self1,
  2. K Bush1,2,
  3. V R Baral2,
  4. N Puvanachandra3,
  5. V F Puddy2,
  6. P Hodgkins1
  1. 1Eye Unit, Southampton General Hospital, Southampton, UK
  2. 2Neonatal Unit, Princess Anne Hospital, Southampton, UK
  3. 3Norfolk and Norwich University Hospital, Norwich, UK
  1. Correspondence to Dr Kate Bush, Royal Bournemouth, Castle Lane East, Bournemouth, Dorset BH7 7DW, UK; akoh199{at}

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Diamniotic, dichorionic, male in vitro fertilisation (IVF) twins were born at 26+6 weeks. Retinopathy of prematurity screening revealed bilateral posterior pole retinoblastoma in twin A at 34 weeks' gestation. Aggressive chemoreduction therapy regressed the tumours significantly, which await definitive treatment (figure 1). Genetic analyses identified a heterozygous mutation in the RB1 gene in the affected twin that was absent …

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  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; internally peer reviewed.