Article Text

Download PDFPDF
Perinatal Outcome of Preterm Infants <1500 g after IVF pregnancies compared with natural conception
  1. A Messerschmidt1,
  2. M Olischar2,
  3. R Birnbacher3,
  4. M Weber4,
  5. A Pollak1,
  6. H Leitich5
  1. 1Division of General Pediatrics and Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Austria
  2. 2Department of Neonatology, The Royal Children's Hospital, Victoria, Australia
  3. 3Department of Pediatrics and Adolescent Medicine, Hospital of Villach, Austria
  4. 4Department of Radiology, Medical University of Vienna, Austria
  5. 5Division of Obstetrics and Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, Medical University of Vienna, Austria
  1. Correspondence to Dr Agnes Messerschmidt, Division of General Pediatrics and Neonatology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Austria; agnes.messerschmidt{at}


Objective In vitro fertilisation (IVF) pregnancies are at increased risk for adverse perinatal outcome including very low birth weight infants. The purpose of this study was to find out whether the perinatal outcome of preterm infants <1500 g after IVF is different from those in naturally conceived pregnancies.

Patients and methods This retrospective cohort study included preterm infants <1500 g born between 1999 and 2007 in a tertiary perinatal referral centre. All analyses were made separately for singletons and multiples, divided into infants <1000 g and 1000–1499 g. The primary study outcomes were infant mortality, short term pulmonary morbidity and cerebral morbidity. The secondary study outcomes were small for gestational age, Apgar score at 5 min, the results of the first venous blood gas analysis of the preterm infant, and the first mean arterial blood pressure after neonatal intensive care unit admission. Logistic regression analysis was done to assess the impact of IVF compared to other maternal and infant factors.

Results 1423 patients (195 IVF and 1228 non-IVF patients) were included in this study. The incidence of preterm labour was significantly higher in multiples after IVF than in spontaneously conceived multiples. In the IVF group, there were significantly more multiples. Mortality, pulmonary morbidity and cerebral morbidity did not differ among patients after IVF and naturally conceived patients. Also, there were no significant differences for the secondary outcomes, except for a significantly higher initial pH value in multiples after IVF between 1000–1499 g.

Conclusion IVF treatment was not associated with adverse outcome in very low birth weight infants.

IVF, preterm birth, VLBW, singletons, multiples, outcome

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Funding None.

  • Competing interests None.

  • Ethics approval This study was conducted with the approval of the Medical University Vienna, Austria.

  • Provenance and peer review Not commissioned; externally peer reviewed.