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Exchange transfusion and intravenous immunoglobulin use in the UK
  1. G Y T Ng1,
  2. I Roberts2,
  3. H V New3
  1. 1
    Department of Neonatology, St Mary’s Hospital, London, UK
  2. 2
    Department of Haematology, Imperial College Healthcare NHS Trust, London, UK
  3. 3
    Department of Paediatrics, St Mary’s Hospital, London, UK
  1. Correspondence to Geraldine Ng, Department of Neonatology, 1st Floor, The Bays Building, Imperial College Healthcare NHS Trust, St Mary’s Hospital, Praed Street, London W2 1NY, UK;{at}

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Phototherapy and exchange blood transfusion are primary treatment modes for significant haemolytic disease of the newborn (HDN), to lower serum bilirubin and reduce risk of kernicterus.1 Incidence of HDN has decreased in recent years and there has been concern over decreased experience in performing exchange transfusions.2

The American Academy of Pediatrics recommends intravenous immunoglobulin (IVIG) use for newborns with HDN due to Rh and ABO incompatibility and rising bilirubin.3 IVIG may be an alternative to exchange transfusion to avoid some …

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  • Competing interests None.

  • Provenance and Peer review Not commissioned; not externally peer reviewed.