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Lenticulostriate vasculopathy in very preterm infants
  1. L M Leijser1,
  2. S J Steggerda1,
  3. F T de Bruïne2,
  4. A van Zuijlen1,
  5. A van Steenis1,
  6. F J Walther1,
  7. G van Wezel-Meijler1
  1. 1
    Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands
  2. 2
    Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
  1. Correspondence to Lara M Leijser, Department of Pediatrics, Division of Neonatology, J6-S, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands; l.m.leijser{at}


Objective: To assess for lenticulostriate vasculopathy (LSV) on cranial ultrasound (cUS) scans of very preterm infants: incidence and aetiology, evolution during neonatal period, association with clinical parameters, and MRI equivalent.

Design: Prospective study.

Setting: Tertiary neonatal referral centre.

Patients: Very preterm infants (<32 weeks) underwent sequential cUS throughout the neonatal period and MRI around term age. cUS were evaluated for LSV and other changes, and MRI for changes in signal and myelination in deep grey matter. LSV was divided into early-onset (⩽7 postnatal days) and late-onset (>7 postnatal days). Perinatal clinical parameters were collected for all infants and compared between groups.

Results: In 22/111 (20%) infants LSV was detected: early-onset in 5 and late-onset in 17. LSV mostly presented some weeks after birth and persisted for several months. There were no associations between LSV and other changes on cUS or deep grey matter changes on MRI. Infants with late-onset LSV were younger and smaller at birth than infants with early-onset LSV. Postmenstrual age at first detection was comparable for both LSV groups. There were no associations between LSV and perinatal clinical parameters, but infants with LSV had less episodes of hypotension than infants without LSV.

Conclusions: LSV is a frequent finding on cUS in very preterm infants, but does not show on MRI. The postmenstrual age, rather than gestational and postnatal age, seems important in LSV development. LSV is not associated with clinical parameters. When encountered in otherwise healthy preterm infants, LSV is probably a benign temporary phenomenon.

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  • Funding This project was supported by a grant 920-03-388 from ZonMw, the Netherlands Organisation for Health Research and Development.

  • Competing interests None.

  • Provenance and Peer review Not commissioned; externally peer reviewed.

  • Ethics approval The study was approved by the Medical Ethics Committee.

  • Patient consent Parental consent obtained.