The postnatal management of severe congenital diaphragmatic hernia (CDH) remains challenging with few robust evidence-based interventions but many therapies based on case reports or small case series. A good example of this is sildenafil, a phosphodiesterase inhibitor, which is increasingly used in the management of pulmonary hypertension associated with CDH.1 2

We retrospectively audited sildenafil use in all infants with CDH managed in the co-located Queen Mother’s Hospital and the Royal Hospital for Sick Children, …