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Differences between the amino acid concentrations of umbilical venous and arterial blood
  1. H Tsuchiya1,
  2. K Matsui2,
  3. T Muramatsu3,
  4. T Ando3,
  5. F Endo4
  1. 1
    Department of Pediatrics, Fukuda Hospital, Kumamoto, Japan
  2. 2
    Department of Obstetrics, Fukuda Hospital, Kumamoto, Japan
  3. 3
    Institute of Life Sciences, Ajinomoto Co. Inc., Kawasaki-shi, Japan
  4. 4
    Department of Pediatrics, Kumamoto University Graduate School of Medicine, Kumamoto, Japan
  1. Dr H Tsuchiya, Department of Pediatrics, Fukuda Hospital, Shin-machi 2-2-6, Kumamoto, 860-0004 Japan; tsuchiya{at}

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Amino acids are supplied to the fetus via the umbilical vein (UV). The difference between the amino acid concentrations of the UVs and umbilical arteries (UAs), in other words the umbilical amino acid flux, determines which amino acids are required by the fetus and which ones are sufficient. We analysed amino acid concentrations in the UV and UA blood obtained at birth by using high-performance liquid chromatography (HPLC). We examined 31 singleton, full-term neonates appropriate for gestational age (according to Japanese standards). The Fukuda Hospital Board approved the protocol of this investigation. Informed consent was obtained from all the mothers who …

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  • Competing interests: None.