Background: Premature infants are vulnerable to complications related to oxidative stress. Exposure to light increases oxidation products in solutions of total parenteral nutrition (TPN) such as lipid peroxides and hydrogen peroxide. Oxidative stress impairs glucose uptake and affects lipid metabolism. Hypothesis: products of photo-oxidation contaminating TPN affect lipid metabolism.
Objective: Evaluate the effect of photoprotection of TPN in preterm infants on plasma glucose and triglyceride (TG) concentrations.
Design: Secondary analysis of a prospective study allocating preterm infants to light-exposed (LE, n = 32) or light-protected (LP, n = 27) TPN.
Setting: Level III NICU referral centre for patients of British Columbia.
Patients: Preterm infants requiring TPN.
Interventions and outcome measures: TG and blood glucose measured during routine monitoring while on full TPN were compared between LE and LP.
Results: Clinical characteristics were similar between the two groups (gestational age 28±1 wk; birth weight: 1.0±0.1 kg). Nutrient intakes from TPN and from minimal enteral nutrition were comparable between LE and LP. Blood glucose was higher in preterm infants receiving LE (p<0.001). The accumulation of TG with increasing lipid intake was twice as high with LE accounting for significantly higher TG levels on days 8 and 9 (p<0.05).
Conclusions: Failure to photoprotect TPN may cause alterations in intermediary metabolism. Shielding TPN from light provides a potential benefit for preterm infants by avoiding hypertriglyceridaemia allowing for increased substrate delivery.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Funding: This work was supported by the Canadian Institutes of Health Research (grant: MOP 53270).
Competing interests: None.
Ethics approval: The study was approved by the Clinical Research Ethics Board of the University of British Columbia, and by the Clinical Research Committee of the Children’s and Women’s Health Centre of BC.
Patient consent: Parental written informed consent was obtained prior to enrolment.