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Relationship between vitamin D and alkaline phosphatase in very-low-birthweight infants
  1. R McCarthy1,
  2. N McCallion1,
  3. G Harrison1,
  4. E J Molloy1,2
  1. 1
    Department of Neonatology, National Maternity Hospital, Dublin, Ireland
  2. 2
    UCD School of Medicine and Medical Science, Dublin, Ireland
  1. Dr E Molloy, Department of Neonatology, National Maternity Hospital, Holles Street, Dublin 2, Ireland; emolloy{at}

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Vitamin D deficiency is increasingly recognised in neonates, especially those born to high-risk mothers.1 Term infants at high risk of vitamin D deficiency have higher mean alkaline phosphatase (ALP) activity than controls, indicating increased bone turnover.1 Despite this, ALP activities remain within the normal range in these high-risk infants. There is little research on vitamin D deficiency in very-low-birthweight (VLBW) infants, who are at high risk of bone disease due to osteopenia of prematurity (OP) and potentially maternal or nutritional vitamin D deficiency. The increase in breast feeding with inadequate supplementation …

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  • Competing interests: None.