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West syndrome (WS) is the epileptic encephalopathy caused by various brain disorders. Although severe periventricular leucomalacia in preterm infants is related to later development of WS,1 there have been no studies of WS in extremely preterm infants. We investigated the relation between postnatal events and later development of WS in extremely preterm infants.
Box 1 Definition of late-onset circulatory dysfunction
Hypotension with mean arterial pressure <80% of those before the episode, refractory to volume expanders or inotropic agents.
Electrolyte derangement, including hyponatraemia <130 mEq/l or hyperkalaemia >7 mEq/l, or both.
Oliguria <1 ml/kg/h lasting for 8 hours or longer.
An episode occurred in …
Competing interests: None.
Ethics approval: Approved by the ethics committee of Juntendo University.