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Selective fluconazole prophylaxis in high-risk babies to reduce invasive fungal infection
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  • Published on:
    Practical approach to improve prophylaxis against fungal infections
    • Yoram A Bental, Neonatologist
    • Other Contributors:
      • Imad R. Makhoul- Meyer Children's Hospital and The Bruce Rappaport Faculty of Medicine-Technion, Israel.

    áñ"ã To the Editor, We read with interest the article by McCrossan et al on selective fluconazole prophylaxis. Reviewing the data presented in Table 2, in 3 out of 4 infants with positive blood culture, cephalosporin was involved. A practical conclusion would be to eliminate the use of cephalosporin in VLBW infants. Another measure would be to shorten empiric antibiotic use to 3-4 days (if cultures prove to be negative)...

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    Conflict of Interest:
    None declared.
  • Published on:
    Prophylaxis to reduce fungal infection in neonates
    • Renato S Procianoy, Professor of Pediatrics, Head of the Newborn Section
    • Other Contributors:
      • Rita.C. Silveira

    The study by McCrossan et al showed that fluconazole prophylaxis in a selected group of preterm infants with birth weight less than 1,500 grams decreases invasive fungal infection [1]. We agree that a carefully delineated risk-factor approach to the prevention of Candida infection in neonates may be a useful alternative to continuous fluconazole prophylaxis and may decrease the risk of the emergence of fluconazole-resistan...

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    Conflict of Interest:
    None declared.