Article Text

Download PDFPDF
How has research in the past 5 years changed my clinical practice
  1. Anne Greenough
  1. Professor Anne Greenough, Deparment of Child Health, 4th Floor Golden Jubilee Wing, King’s College Hospital, London SE5 9RS, UK; anne.greenough{at}


This article discusses how research in the past 5 years into management strategies influencing respiratory outcomes has changed (or not changed) the author’s clinical practice. Changes include using inhaled nitric oxide but no longer systemic pulmonary vasodilators in term born infants with pulmonary hypertension. Use of postnatal steroids is now restricted to systemic administration in infants with severe respiratory failure and who are ventilator dependent beyond 2 weeks of age. Infants with bronchopulmonary dysplasia, unless they have pulmonary hypertension, are maintained at oxygen saturation levels of 90–92% rather than ⩾95%. Supine sleeping is instituted in prematurely born infants without contraindications several weeks prior to neonatal discharge to reinforce to parents the importance of supine sleeping their baby at home. Further research is required to identify the optimal respiratory support strategy, particularly for very immature infants.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Funding: Research on the Newborn Unit at King’s College Hospital is supported by the WellChild Trust and Foundation for the Study of Sudden Infant Death.

  • Competing interests: AG has held grants from various ventilator manufacturers; AG had received honoraria for giving lectures and advising various ventilator manufacturers.

  • Abbreviations:
    assist control
    bronchopulmonary dysplasia
    continuous positive airway pressure
    extracorporeal membrane oxygenation
    high frequency oscillatory ventilation
    sudden infant death syndrome
    synchronous intermittent mandatory ventilation
    volume cycled ventilation
    volume targeted ventilation