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Angiotensin-converting enzyme inhibitor fetopathy: long-term outcome
  1. Guido F Laube1,
  2. Markus J Kemper1,
  3. Gregor Schubiger2,
  4. Thomas J Neuhaus1
  1. 1Nephrology Unit, University Children’s Hospital
    Zurich, Switzerland
  2. 2Children’s Hospital
    Lucerne, Switzerland
  1. Dr Guido F Laube, University Children’s Hospital, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland; guido.laube{at}


Fetal exposure to angiotensin-converting enzyme inhibitors (ACEIs) is associated with increased neonatal morbidity and mortality. Long-term follow-up of three patients with fetal ACEI exposure revealed impaired renal function in two, severe hypertension and proteinuria in one and isolated polycythaemia in all three. Careful long-term follow-up of children with ACEI fetopathy is recommended.

  • angiotensin-converting enzyme inhibitor
  • fetopathy
  • neonatal renal failure
  • long-term outcome
  • polycythaemia

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  • Competing interests: None.

  • Abbreviations:
    angiotensin-converting enzyme inhibitor
    glomerular filtration rate