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Neonatal pure red cell aplasia due to anti-M
  1. R F Hinchliffe1,
  2. B Nolan1,
  3. A J Vora1,
  4. R Stamps2
  1. 1Department of Paediatric Haematology, Sheffield Children’s NHS Trust, Sheffield, UK
  2. 2National Blood Service, Sheffield
  1. Correspondence to:
    A J Vora
    Department of Paediatric Haematology, Sheffield Children’s NHS Trust, Western Bank, Sheffield S10 2TH, UK;Ajay.Vora{at}

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Haemolytic disease of the newborn (HDN) is caused by maternal immunoglobulin (Ig) G acting against antigens expressed on mature fetal red cells. Anti-M antibodies active at 37°C are a rare cause of HDN.1 We report data, arising from the investigation of a neonate with severe transient pure red-cell aplasia, indicating that anti-M can cause hypoplastic HDN by inhibition of erythroid precursor growth, as frequently occurs with anti-Kell antibodies.2

A female neonate presented at 4 weeks of age with severe hypoplastic anaemia (haemoglobin 3.7 g/dl, reticulocytes …

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  • Competing interests: None declared.