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Minimising ventilator induced lung injury in preterm infants
  1. S M Donn1,
  2. S K Sinha2
  1. 1Division of Neonatal-Perinatal Medicine, C S Mott Children’s Hospital, University of Michigan Health System, Ann Arbor, MI, USA
  2. 2Department of Paediatrics and Neonatology, The James Cook University Hospital, University of Durham, Middlesbrough, UK
  1. Correspondence to:
    Professor Donn
    F5790, C S Mott Children’s Hospital, 1500 E Medical Center Drive, Ann Arbor, MI, USA 48109-0254; smdonnmd{at}


Ventilator induced lung injury continues to occur at an unacceptably high rate, which is inversely related to gestational age. Although the “new BPD” may not be entirely avoidable in the extremely premature infant, recognition of risk factors and adoption of an appropriate ventilatory strategy, along with continuous real time monitoring, may help to minimise lung damage. This paper will review the pathogenesis of ventilator induced lung injury and strategies that may mitigate it.

  • BPD, bronchopulmonary dysplasia
  • CLD, chronic lung disease
  • CPAP, continuous positive airway pressure
  • HFJV, high frequency jet ventilation
  • HFOV, high frequency oscillatory ventilation
  • PEEP, positive end expiratory pressure
  • PTV, patient triggered ventilation
  • RDS, respiratory distress syndrome
  • bronchopulmonary dysplasia
  • chronic lung disease
  • preterm
  • respiratory disease syndrome
  • ventilator induced lung injury

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  • Competing interests: none declared