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Contribution of inflammation to lung injury and development
  1. S G Kallapur,
  2. A H Jobe
  1. Cincinnati Children’s Hospital, Divisions of Pulmonary Biology and Neonatology, University of Cincinnati, Cincinnati, OH 45229, USA
  1. Correspondence to:
    Dr Kallapur
    Cincinnati Children’s Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA; Suhas.Kallapur{at}


Inflammation interferes with lung development in model systems and is present chronically in the lungs of preterm infants who develop bronchopulmonary dysplasia (BPD). Antenatal inflammation is very commonly associated with preterm deliveries, but there is generally minimal information about the duration, intensity, or organisms associated with chorioamnionitis. In preterm lamb models, chorioamnionitis causes a lung injury similar to BPD and also causes clinical lung maturation. Continuous exposure of the developing lung before and after delivery to inflammation may be central to the development of BPD.

  • BPD, bronchopulmonary dysplasia
  • CPAP, continuous positive airway pressure
  • IL, interleukin
  • RDS, respiratory distress syndrome
  • respiratory distress syndrome
  • bronchopulmonary dysplasia
  • cytokines
  • surfactant
  • mechanical ventilation

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  • Competing interests: none declared