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Umbilical cord blood procalcitonin and C reactive protein concentrations as markers for early diagnosis of very early onset neonatal infection
  1. N Joram1,
  2. C Boscher1,
  3. S Denizot1,
  4. V Loubersac2,
  5. N Winer3,
  6. J C Roze1,
  7. C Gras-Le Guen1
  1. 1Département de Périnatologie, Hôpital Mère Enfant, Nantes, France
  2. 2Laboratoire de Biochimie, Nantes
  3. 3Service de Gynécologie Obstétrique, Hôpital Mère Enfant, Nantes
  4. 4Laboratoire d’Antibiologie, Faculté de Médecine, Nantes
  1. Correspondence to:
    Dr Gras-le Guen
    Département de Périnatologie, Hôpital Mère Enfant, Quai Moncousu, Chu Nantes, Nantes 44000, France; christele.grasleguen{at}


Procalcitonin (PCT) and C reactive protein (CRP) concentrations in umbilical cord blood of 197 neonates were measured to evaluate their value as markers of infection. Sixteen of the neonates were infected. The sensitivity, specificity, and negative and positive predictive values were respectively 87.5%, 98.7%, 87.5%, and 98.7% for PCT and 50%, 97%, 67%, and 94% for CRP. Serum PCT in cord blood seems to be a useful and early marker of antenatal infection.

  • CRP, C reactive protein
  • PCT, procalcitonin
  • cord blood
  • maternofetal infection
  • procalcitonin
  • C reactive protein

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  • Competing interests: none declared