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Outcome of antenatally suspected congenital cystic adenomatoid malformation of the lung: 10 years’ experience 1991–2001
  1. J K Calvert1,
  2. P A Boyd2,
  3. P C Chamberlain3,
  4. S Said4,
  5. K Lakhoo4
  1. 1Neonatal Unit, John Radcliffe Hospital, Oxford OX3 9DU, UK
  2. 2National Perinatal Epidemiology Unit, University of Oxford, Oxford OX3 7LF
  3. 3Prenatal Diagnosis Unit, Women’s Centre, John Radcliffe Hospital
  4. 4Department of Paediatric Surgery, John Radcliffe Hospital
  1. Correspondence to:
    Dr Calvert
    Neonatal Unit, John Radcliffe Hospital, Oxford OX3 9DU, UK; jenny.calvert{at}


Objective: To determine the outcome of antenatally suspected congenital cystic adenomatoid malformation of the lung (CCAM) over a 10 year period.

Methods: This is a retrospective study of all babies diagnosed antenatally in the Prenatal Diagnosis Unit and delivered in Oxford between 1991 and 2001. Data were obtained from the Oxford Congenital Anomaly Register, theatre records, and histopathology reports.

Results: Twenty eight cases of CCAM were diagnosed antenatally. Five pregnancies were terminated. Data are available on all 23 of the pregnancies that continued and resulted in two neonatal deaths and 21 surviving babies. Eleven of the 23 cases (48%) showed some regression of the lesion antenatally, and four of these cases appeared to resolve completely on prenatal ultrasound. Three of the 23 babies (13%) were symptomatic in the early neonatal period, and three developed symptoms shortly afterwards. Seventeen of the 23 babies (74%) were asymptomatic, of whom 12 had abnormalities on chest radiograph or computed tomography scan and had elective surgery. Two babies (8%) had completely normal postnatal imaging, and three had abnormalities which resolved in the first year of life. Seventeen of the 23 babies (74%) had surgery. Histology at surgery was heterogeneous. Of the 23 live births, all 21 survivors (91%) are well at follow up or have been discharged.

Conclusions: All babies diagnosed antenatally with CCAM require postnatal imaging with computed tomography irrespective of signs of antenatal resolution. In asymptomatic infants, the recommendations are close follow up and elective surgery for persistent lesions within the first year of life. Histology at surgery was heterogeneous, and this should be considered when counselling parents.

  • CCAM, congenital cystic adenomatoid malformation of the lung
  • CT, computed tomography
  • antenatal
  • congenital
  • cystic
  • adenomatoid
  • lung

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  • Published online first 30 August 2005

  • Competing interests: none declared

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