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Chitotriosidase in neonates with fungal and bacterial infections
  1. I Labadaridis1,
  2. E Dimitriou2,
  3. M Theodorakis1,
  4. G Kafalidis1,
  5. A Velegraki3,
  6. H Michelakakis2
  1. 1Neonatal Intensive Care Unit, General Hospital of Nikea, Piraeus, Greece
  2. 2Institute of Child Health, Agia Sophia Children’s Hospital, Athens, Greece
  3. 3Mycology Reference Laboratory, Medical School, University of Athens, Athens, Greece
  1. Correspondence to:
    Helen Michelakakis
    Department of Enzymology and Cellular Function, Institute of Child Health, Agia Sophia Children’s Hospital, 11527 Athens, Greece;


Increased plasma and/or urine chitotriosidase activity was found in neonates with fungal infection changing in parallel with their clinical condition. Increased levels were also found in neonates with bacterial infection. Chitotriosidase activity increase is not a response specific to fungi, but serial assays could monitor the course of neonatal fungal infection.

  • chitotriosidase
  • fungal-bacterial infection
  • neonates

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  • Competing interests: none declared