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Neonatal buccal cell collection for DNA analysis
  1. G Gavriel1,
  2. N Modi1,
  3. P Stanier2,
  4. G E Moore2
  1. 1Faculty of Medicine, Division of Paediatrics, Obstetrics and Gynaecology, Imperial College London, Chelsea & Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK
  2. 2Faculty of Medicine, Division of Paediatrics, Obstetrics and Gynaecology, Institute of Reproductive and Developmental Biology, Imperial College London, Du Cane Road, London W12 0NN, UK
  1. Correspondence to:
    Dr Modi
    n.modiimperial.ac.uk

https://doi.org/10.1136/adc.2004.062661

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    It is considered undesirable to take blood from an infant as a means of obtaining DNA for research purposes. Sufficient DNA for direct gene analysis can be obtained from adult buccal epithelial cells,1 but there is no evidence that neonatal buccal epithelial cells can similarly be used. We have carried out a preliminary study, approved by the Riverside Research Ethics Committee, to determine the ease of isolating neonatal buccal cells for DNA extraction followed by polymerase chain reaction (PCR) and sequence analysis.

    Buccal cells were …

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    Footnotes

    • Competing interests: none declared