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Cytokine polymorphisms and chronic lung disease in small preterm infants
  1. H C Lin1,
  2. F-J Tsai1,3,
  3. C H Tsai1,4,
  4. Y-Y Hsieh2,
  5. C M Hsu3
  1. 1Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan
  2. 2Department of OBS GYN, China Medical University Hospital
  3. 3Department of Medical Genetics, China Medical University Hospital
  4. 4Taichung Healthcare and Management University, Taichung
  1. Correspondence to:
    Professor Fuu-Jen Tsai
    Department of Medical Genetics and Pediatrics, China Medical University Hospital, No 2 Yu-Der Road, Taichung, 404, Taiwan;

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There is increasing evidence that pulmonary inflammation contributes to the pathogenesis of chronic lung disease (CLD).1 Cytokines are key factors in the inflammatory response. The response of various cytokines to stressful stimuli have been shown to be partly due to interindividual variation at a genetic level.2 The possibility that genetic factors play a role in susceptibility to CLD has been reported.3,4 We decided to investigate whether gene polymorphisms for tumour necrosis factor α (TNFα-308 G/A) and interleukin …

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  • Competing interests: none declared