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Hospital admissions for bronchiolitis in preterm infants in the absence of respiratory syncytial virus prophylaxis
  1. P Bala,
  2. C A Ryan,
  3. B P Murphy
  1. Department of Paediatrics and Child Health, University College Cork, Ireland;

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Respiratory syncytial virus (RSV) is the causative agent in more than 50% of cases of bronchiolitis, with mycoplasma pneumonia, Para influenza 3, adenovirus, and some other viruses accounting for most of the remaining cases. Mortality from bronchiolitis ranges from 1% to 3%. Although as yet there is no safe and effective vaccine, passive immunity with Palivizumab has been shown to reduce hospital admissions of preterm babies, but no reduction in mortality, intensive care admissions, or ventilation days was observed.1 Critical appraisal of this study reveals that the number of infants to be treated to prevent one hospital admission is between 17 and 22.

The objectives of our study were to document local admission rates of premature infants from clinical bronchiolitis, assess local mortality and morbidity secondary to bronchiolitis, and examine seasonal and annual variation of bronchiolitis admissions. By examining hospital admission databases in Cork University Hospital, all admissions between 1997 and 2001 for clinical bronchiolitis, including intensive care admissions, were identified. Parents of premature infants (32 weeks) born in the Maternity Services in Cork in 1997–2001 were contacted by telephone and postal questionnaire, with a response rate 82%.

Thirty five of 174 babies (20%) were admitted for bronchiolitis over this five year period. Total hospital inpatient stay was 175 days. Average length of stay was five days per infant. Peak incidence of bronchiolitis in our region was between November and March. Whereas the number of preterm infants < 32 weeks born in our region increased over the years, the percentage admitted with bronchiolitis decreased (fig 1). None of the preterm infants admitted with bronchiolitis required admission to the intensive care unit. Indeed only five infants, all born at term gestation without underlying conditions, required intensive care admission and ventilation for clinical bronchiolitis during this time. There were no deaths from bronchiolitis in either premature or term infants.

Figure 1

 Premature births (< 32 weeks) and bronchiolitis admission rates over five years.

Palivizumab cost € 940 and € 564 per 100 and 50 mg vial respectively. At a dose of 15 mg per kg, with five doses per season (as recommended by the American Academy of Paediatrics), provision of prophylaxis to all our premature babies (32 weeks) would cost > € 400 000 compared with inpatient hospital cost for premature infants with bronchiolitis approximating < € 50 000.

Bronchiolitis due to RSV and other viruses is still a major problem in preterm infants. The role of parental education (RSV: Reduce exposure, no Smoking, Very good hand washing) has not been evaluated. We believe that, given the absence of a reduction in mortality and significant morbidity (ventilation, admissions to intensive care), the role of Palivizumab for RSV prophylaxis for premature infants remains questionable, with the potential long term benefit of RSV prophylaxis as yet undetermined.



  • Competing interests: none declared

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