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Ibuprofen and cerebral oxygenation and circulation
  1. G Naulaers1,
  2. G Delanghe1,
  3. K Allegaert1,
  4. A Debeer1,
  5. V Cossey1,
  6. C Vanhole1,
  7. P Casaer1,
  8. H Devlieger1,
  9. B Van Overmeire2
  1. 1Neonatal Intensive Care Unit, University Hospital Leuven, Herestraat 49 3000 Leuven, Belgium
  2. 2Neonatal Intensive Care Unit, University Hospital Antwerp, Antwerp, Belgium
  1. Correspondence to:
    Dr Naulaers
    Neonatal Intensive Care Unit, Department of Paediatrics, University Hospital Leuven, Herestraat 49, 3000 Leuven, Belgium;


The effect of prophylactic administration of ibuprofen on the cerebral circulation in preterm babies was measured with near infrared spectroscopy. No significant difference in the change in cerebral blood volume, change in cerebral blood flow, or tissue oxygenation index was found between administration of ibuprofen or placebo.

  • CBV, cerebral blood volume
  • Hb, reduced haemoglobin
  • HbO2, oxyhaemoglobin
  • HbD, cerebral intravascular oxygenation (HbO2− Hb)
  • HbT, total haemoglobin
  • TOI, tissue oxygenation index
  • near-infrared spectroscopy
  • ibuprofen
  • tissue oxygenation index
  • cerebral blood flow

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  • Competing interests: none declared

  • Support grants: Research of GN supported by FWO: Clinical Doctoral Grant A6/5-CM.D 11.354.

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