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Hydrofluoroalkane-beclomethasone versus chlorofluorocarbon-beclomethasone delivery in neonatal models

Abstract

Dose delivery of hydrofluoroalkane-beclomethasone and chlorofluorocarbon-beclomethasone was compared during in vitro neonatal simulations: mechanical ventilation with 40% and 100% relative humidity + Neonatal Chamber-Ventilator System/endotracheal tube; manual ventilation + Neonatal Chamber/endotracheal tube; “spontaneous breathing” + Neonatal Chamber/face mask without/with manual assistance. The delivery of hydrofluoroalkane-beclomethasone was significantly greater in each simulation.

  • CFC-BDP, chlorofluorocarbon-beclomethasone dipropionate
  • HFA-BDP, hydrofluoroalkane-beclomethasone dipropionate
  • aerosol therapy
  • inhalants
  • glucocorticoid
  • bronchopulmonary dysplasia

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