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Massive acute haemolysis in neonates with glucose-6-phosphate dehydrogenase deficiency
  1. A S Dhillon1,
  2. P J Darbyshire2,
  3. M D Williams2,
  4. J G Bissenden3
  1. 1Department of Neonatology, Birmingham Women’s Hospital, Birmingham B15 2TG, UK
  2. 2Department of Haematology, Birmingham Children’s Hospital, Birmingham B4 6NH
  3. 3Department of Paediatrics, City Hospital, Birmingham B18 7QH
  1. Correspondence to:
    Dr Dhillon
    Neonatal Unit, Birmingham Women’s Hospital, Edgbaston, Birmingham B15 2TG UK;


Three neonates with glucose-6-phosphate dehydrogenase (G6PD) deficiency are described. All three patients suffered an episode of massive acute haemolysis, in the absence of blood group incompatibilities, infection, or ingestion of oxidising agents known to trigger haemolysis. One patient died, but the other two survived after an exchange transfusion. This highlights that G6PD deficiency in the neonatal period may present with severe anaemia in association with hyperbilirubinaemia.

  • glucose-6-phosphate dehydrogenase deficiency
  • haemolysis
  • hyperbilirubinaemia
  • anaemia
  • transfusion
  • DCT, direct Coombs test
  • G6PD, glucose-6-phosphate dehydrogenase
  • Hb, haemoglobin concentration
  • TPN, total parenteral nutrition
  • WCC, white cell count

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