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Systematic review of intravenous immunoglobulin in haemolytic disease of the newborn
  1. A G Cleary1,
  2. B Brown1,
  3. J Minards1,
  4. J Sills1,
  5. P Bolton-Maggs2
  1. 1Royal Liverpool Children’s Hospital, Liverpool, UK;
  2. 2Manchester Haemophilia Comprehensive Care Centre, Department of Clinical Haematology, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK

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    We read with interest the recent review of Gottstein and Cooke.1 Their systematic review of trials reporting treatment of infants with proven Rh and/or ABO haemolytic disease of the newborn (HDN) treated with high dose intravenous immunoglobulin (HDIVIG) and phototherapy, with phototherapy alone demonstrated that significantly fewer infants required exchange transfusion in the HDIVIG group. The authors point out that anti-D is the commonest red cell antibody responsible for HDN. We have recently treated two children both of whom developed evidence of immune haemolysis due to anti-D antibodies acquired from IVIG.

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