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Neonatologists are using much less dexamethasone
  1. E S Shinwell1,
  2. M Karplus2,
  3. D Bader3,
  4. S Dollberg4,
  5. I Gur5,
  6. Z Weintraub6,
  7. S Arnon7,
  8. E Gottfreid8,
  9. A Zaritsky9,
  10. I R Makhoul10,
  11. D Reich11,
  12. L Sirota12,
  13. I Berger13,
  14. A Kogan14,
  15. S Yurman15,
  16. M Goldberg16,
  17. D Kohelet17
  1. 1Kaplan Medical Center, Rehovot, Israel
  2. 2Soroka Medical Center, Beersheva, Israel
  3. 3Bnei Zion Hospital, Haifa, Israel
  4. 4Sourasky Medical Center, Tel Aviv, Israel
  5. 5Bikur Holim Hospital, Jerusalem, Israel
  6. 6Carmel Hospital, Haifa
  7. 7Meir Hospital, Kfar Saba, Israel
  8. 8Ziv Hospital, Tsfat, Israel
  9. 9Barzilai Hospital, Ashkelon, Israel
  10. 10Rambam Hospital, Haifa
  11. 11Ha’emek Hospital, Afula, Israel
  12. 12Schneider Children’s Hospital, Petach Tikva, Israel
  13. 13Western Galilee Hospital, Nahariya, Israel
  14. 14Sheba Medical Center, Tel Hashomer, Israel
  15. 15Hillel Yaffe Hospital, Hadera, Israel
  16. 16Assaf Harofe Hospital, Tsrifin, Israel
  17. 17Wolfson Hospital, Holon, Israel
  1. Correspondence to:
    Dr Shinwell, Department of Neonatology, Kaplan Medical Center, PO Box 1, Rehovot, Israel;
    eric_s{at}clalit.org.il

Abstract

Two historical cohorts (1993–1994 and 2001) of preterm infants ventilated for respiratory distress syndrome were compared. Dexamethasone administration fell from 22% to 6%. Chronic lung disease in survivors rose slightly from 13% to 17%, and mortality fell from 21% to 15% (other causes). The effect of restriction of dexamethasone use on chronic lung disease and mortality remains to be seen.

  • dexamethasone
  • corticosteroids
  • preterm
  • chronic lung disease
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