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Very early preterm infants are born at a time when more than 90% of their red blood cells contain fetal haemoglobin (HbF)1 and therefore their blood has a high affinity for oxygen.2 Because of blood sampling, early preterm newborns often receive transfusions for blood volume replacement. These transfusions are carried out with adult red blood cells containing adult haemoglobin (HbA) and decrease the HbO2 affinity.
The change in P50 after transfusion has not previously been published in human preterm …