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Whitelaw et al1 recently reported that S-100 protein concentration was 20–200 times higher than control levels in the cerebrospinal fluid of infants with posthaemorrhagic ventricular dilatation. S-100 protein is produced only within the brain by astrocytes, but it can be detected in the serum after cerebral damage in adults with stroke, where it is a marker of infarction volume,2 and it has also been found to be useful in head injury.3 A study of term infants found that serum S-100 …