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S100 protein content of umbilical cord blood in healthy newborns in relation to mode of delivery
  1. J W Wirds1,
  2. A E J Duyn2,
  3. S D Geraerts3,
  4. E Preijer5,
  5. J A A M van Diemen-Steenvoorde3,
  6. J H Schagen van Leeuwen2,
  7. F J L M Haas4,
  8. W B M Gerritsen4,
  9. A de Boer5,
  10. J A Leusink1
  1. 1Department of Anesthesiology, St Antonius Hospital, Nieuwegein, The Netherlands
  2. 2Department of Gynecology and Obstetrics, St Antonius Hospital
  3. 3Department of Pediatrics, St Antonius Hospital
  4. 4Clinical Laboratory, St Antonius Hospital
  5. 5Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences, Utrecht, The Netherlands
  1. Correspondence to:
    Dr Wirds, PO Box 2500, 3430 EM Nieuwegein, The Netherlands;


Background: Early detection and quantification of brain damage in neonatal asphyxia is important. In adults, S100 protein in blood is associated with damage to the central nervous system.

Objective: To determine whether S100 protein can be detected in arterial and venous cord blood of healthy newborns and to relate S100 protein concentrations in cord blood to mode of delivery.

Method: S100 protein levels in umbilical cord blood of 81 healthy infants were determined.

Results: S100 protein was present in arterial (median concentration 1.62 μg/l) and venous (median concentration 1.36 μg/l) cord blood. Levels were significantly higher in vaginal births (median arterial concentration 1.72 μg/l; median venous concentration 1.48 μg/l) than births by caesarean section (1.51 μg/l and 1.26 μg/l respectively).

Conclusion: More research is necessary to determine whether S100 protein is a useful marker in neonatal asphyxia.

  • S100 protein
  • cord blood
  • delivery mode
  • asphyxia
  • brain damage

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