Article Text

Download PDFPDF
Retinopathy of prematurity: recent advances in our understanding
  1. C M Wheatley1,
  2. J L Dickinson2,
  3. D A Mackey3,
  4. J E Craig3,
  5. M M Sale2
  1. 1Discipline of Biochemistry, University of Tasmania, Hobart, Tasmania, Australia
  2. 2Menzies Centre for Population Health Research, University of Tasmania, Hobart, Tasmania, Australia
  3. 3Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia
  1. Correspondence to:
    Michéle Sale, PhD, Menzies Centre for Population Health Research, University of Tasmania, GPO Box 252-23, Hobart, Tasmania 7001, Australia;


Retinopathy of prematurity (ROP) has been recognised as an important cause of childhood visual impairment and blindness since the 1940s when improved facilities and treatment increased the survival rate of premature infants. Although its incidence and severity have been decreasing in developed countries over the past two decades, both are increasing in developing nations. ROP is consequently targeted as an important but avoidable disease. This review provides an updated summary and discussion of much of the work that has been produced through population, animal, cell culture, and genetic research. The authors examine the prevalence, risk factors, and possible causes of the disease with a particular focus on genetic studies. They conclude that while significant reductions in the disease have occurred in developed countries, further research is required to fully understand and prevent the disease. In the meantime, development and implementation of appropriate screening and treatment strategies will be critical in reducing blindness in developing countries.

  • retinopathy of prematurity
  • children

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Reproduced in full with permission from Br J Ophthalmol 2002:86:696–700