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Case reports
Neonatal alloimmune thrombocytopenia with significant HLA antibodies
  1. J D Grainger1,
  2. G Morrell2,
  3. J Yates2,
  4. D Deleacy2
  1. 1Department of Haematology, Manchester Children's Hospital, Pendlebury, Manchester M27 4HA, UK
  2. 2Manchester Blood Centre, Plymouth Grove, Manchester, UK
  1. Correspondence to:
    Dr Grainger, Department of Haematology, Manchester Children's Hospital, Pendlebury, Manchester M27 4HA, UK;
    jgrainger{at}bigfoot.com

Abstract

A case of neonatal alloimmune thrombocytopenia (NAIT) secondary to human platelet antigen (HPA)-1a antibodies is reported. Additional multispecific HLA antibodies rendered volunteer donor platelet transfusions ineffective. Despite a high incidence of maternal HLA antibodies in the pregnant population, there is only one previous report of clinically significant HLA antibodies.

  • neonatal alloimmune thrombocytopenia (NAIT)
  • HLA antibodies
  • apheresis
  • platelet transfusion
  • NAIT, neonatal alloimmune thrombocytopenia
  • HPA, human platelet antigen

https://doi.org/10.1136/fn.86.3.F200

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