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Posthaemorrhagic ventricular dilatation
  1. A Whitelaw1,
  2. M Thoresen1,
  3. I Pople2
  1. 1Division of Child Health, University of Bristol, Bristol, UK
  2. 2Department of Neurosurgery, Frenchay Hospital, Bristol, UK
  1. Correspondence to:
    Professor Whitelaw, Division of Child Health, University of Bristol Medical School, Southmead Hospital, Bristol BS9 1PJ, UK;


Posthaemorrhagic ventricular dilatation is the most serious direct complication of intraventricular haemorrhage after preterm birth. It results initially from multiple small blood clots throughout the cerebrospinal fluid channels impeding circulation and reabsorption. Management is difficult and new treatment approaches are needed.

  • preterm
  • intraventricular haemorrhage
  • hydrocephalus
  • transforming growth factor β
  • tissue plasminogen activator
  • IVH, intraventricular haemorrhage
  • PHVD, posthaemorrhagic ventricular dilatation
  • CSF, cerebrospinal fluid
  • TGFβ1, transforming growth factor β1

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