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Effect of enteral administration of insulin on intestinal development and feeding tolerance in preterm infants: a pilot study
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  • Published on:
    Re: Addition of insulin to infant formula

    To The Editor:

    I am familiar with the work of Dr Shehadeh et al. There may indeed be a place for insulin in infant formula. However, before such a step is taken, I believe that it is imperative that appropriate prospective studies be done, including safety monitoring. Although our human pilot study and animal studies suggest there may be a benefical effect of oral insulin, much more work needs to be done...

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    Conflict of Interest:
    None declared.
  • Published on:
    Addition of insulin to infant formula
    • Naim Shehadeh, Head, Juvenile Diabetes Unit
    • Other Contributors:
      • Raanan Shamir

    Dear Editor

    I read with great interest the article by Shulman.[1] Indeed, orally administered insulin may have a positive effect on gut maturation and mucosal enzyme expression in preterm infants. We have recently demonstrated that human milk is rich in insulin (mean = 60.2 micro U/ml), and that insulin is barely detected in infant formulas.[2] Moreover, we have hypothesized that insulin content of human milk may ha...

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    Conflict of Interest:
    None declared.