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A trial of recombinant human granulocyte colony stimulating factor for the treatment of very low birthweight infants with presumed sepsis and neutropenia
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  • Published on:
    Use of rhG-CSF for VLBW babies with presumed sepsis and neutropoenia
    • Girish Gupta, Medical teacher
    • Other Contributors:
      • Venkatnarayan K, Wilson CG, Nair MNG

    Dear Editor

    We read with great enthusiasm the article on use of rhG-CSF for treatment of sepsis in VLBW by Bedford et al.[1] It emphasises the previous studies on the subject of potential use of rhG-CSF in management of neonatal sepsis, especially given its fewer side effects and its significant effect on neutrophil counts.

    While it is true that VLBW neonates have low neutrophil counts and storage pool...

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    Conflict of Interest:
    None declared.
  • Published on:
    Re: Recombinant human granulocyte colony stimulating factor therapy in neonates

    Dear Editor,

    We thank Drs Jog and Patole for their extremely valid comments regarding our paper, which provide us with the opportunity to share the information requested. The complete dataset was omitted in the interests of brevity and summarised in the statement that there were no significant differences in maternal and peripartum characteristics between the two groups.

    Antenatal steroids were administe...

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    Conflict of Interest:
    None declared.
  • Published on:
    Recombinant human granulocyte colony stimulating factor therapy in neonates
    Dear Editor,

    We read with interest the article by Bedford Russell et al on the use of rhG-CSF in very low birth weight neonates with presumed sepsis in a prospective randomised, placebo controlled trial. [1] Considering that the safety (primary objective) and efficacy of rhG-CSF (secondary outcome) was evaluated by factors like worsening of respiratory distress syndrome or chronic lung disease (CLD), thrombocytopenia, ri...

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    Conflict of Interest:
    None declared.