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Original article
Brain specific proteins in posthaemorrhagic ventricular dilatation
  1. A Whitelawa,
  2. L Rosengrenb,
  3. M Blennowc
  1. aDivision of Child Health, University of Bristol, Bristol, UK, bDepartment of Neurology, Sahlgrenska Hospital, Gothenburg, Sweden, cDepartment of Paediatrics, Huddinge Hospital, Huddinge, Sweden
  1. Professor Whitelaw, Division of Child Health, University of Bristol Medical School, Southmead Hospital, Bristol BS10 5NB, UK email: andrew.whitelaw{at}bristol.ac.uk

Abstract

Median neurofilament and glial fibrillary acidic protein concentrations in the cerebrospinal fluid of 18 infants with posthaemorrhagic ventricular dilatation were 20–200 times higher than control values. S-100 protein in cerebrospinal fluid was four times higher than control values. Glial fibrillary acidic protein concentrations correlated with death or disability and with parenchymal lesions but not with shunt dependence.

  • cerebrospinal fluid
  • glial fibrillary acidic protein
  • posthaemorrhagic ventricular dilatation
  • brain
  • neurodevelopment

https://doi.org/10.1136/fn.84.2.F90

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