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Neonatal paroxetine withdrawal syndrome


Four term neonates presented with symptoms such as jitteriness and necrotising enterocolitis after paroxetine exposure in utero.

Key messages

Key messages

  • Paroxetine withdrawal syndrome was suspected in four neonates exposed to the drug in utero at maternal doses ranging from 20 to 120 mg/day

  • The symptoms and abnormalities included, but were not limited to, jitteriness, vomiting, irritability, hypoglycaemia, and necrotising enterocolitis

  • Close observation is warranted for neonates exposed to paroxetine in utero

  • neonates
  • paroxetine
  • withdrawal
  • serotonin reuptake inhibitors
  • necrotising enterocolitis

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