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Fetal brain disruption sequence in a newborn infant with a history of cordocentesis at 21 weeks gestation
  1. N Villó,
  2. J Beceiro,
  3. M Cebrero,
  4. E Garcia de Frias
  1. Department of Pediatrics, University Hospital Principe de Asturias, Alcalá de Henares, Madrid, Spain
  1. Dr Villó, Servicio de Pediatria, Hospital Universitario Príncipe de Asturias, Carretera de Alcalá-Meco s/n, Alcalá de Henares, Madrid, España email:jbeceiro{at}


The case is reported of a full term infant with severe microcephaly, overlapping sutures, prominence of the occipital bone, and scalp rugae. No other associated malformations were observed. The only obstetric history of interest was the performance of cordocentesis at 21 weeks gestational age because of low maternal α fetoprotein levels. Ultrasound scans performed until then were normal. Cranial growth retardation was detected on ultrasound scanning at 25 weeks and intrauterine growth retardation as well as severe microcephaly at 34 weeks. Neuroimaging studies performed on the newborn infant showed intense cerebral atrophy in both hemispheres. Other complementary investigations gave negative results. A relation is proposed between the cordocentesis and the development of vascular disruption, which could have caused the fetal brain disruption sequence in this case.

  • cordocentesis
  • microcephaly
  • disruption
  • vascular encephalopathy
  • brain
  • cerebral atrophy

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