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Study of maternal influences on fetal iron status at term using cord blood transferrin receptors
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  • Published on:
    Translational regulation of TfR and ferritin - Authors' response
    Dear Editor

    We thank Peter Reynolds for his continuing interest in our recent article.[1] In his first letter[2] he made a number of interesting points to which we responded.[3] He has now clarified[4] a point raised in his first letter. This turns out to be our inadvertent use of the word "transcription" when we meant "translation" in the discussion section of our original paper.[1] We apologise for this oversig...

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    Conflict of Interest:
    None declared.
  • Published on:
    Translational regulation of TfR and ferritin
    Dear Editor,

    I thank Professors Halliday and Lappin for their riposte.[1] They suggest that I wish to describe the control of intracellular iron as "post-translational". That is an incorrect reading of my earlier response, where I described the control as "translational".[2]

    In their original article (and I quote) "Simultaneously, in a highly coordinated process IRPs bind to the 5' end of the ferritin gene an...

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    Conflict of Interest:
    None declared.
  • Published on:
    Newborns have unique confounding factors regarding the TfR-F ratio - Authors' response
    Dear Editor,

    We thank Peter Reynolds for congratulating us for adding a piece to the jigsaw of fetal iron metabolism.[1] We would like to reply to some of his other comments. We feel that use of the term post-transcriptional to describe the regulation of intracellular iron metabolism was correct rather than post-translational as suggested by Reynolds. Iron regulatory elements (IREs) are stem cell loop structures of s...

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    Conflict of Interest:
    None declared.
  • Published on:
    Newborns have unique confounding factors regarding the TfR-F ratio
    Dear Editor,

    Sweet et al investigated the serum transferrin receptor (sTfR) and, for the first time in neonates, transferrin receptor-log ferritin (TfR-F) ratio in a prospective series of cord blood taken from term infants and their mothers. They are to be congratulated on completing another piece of the complex jigsaw that is fetal and neonatal iron metabolism.

    sTfR and TfR-F were increased in iron deficient m...

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    Conflict of Interest:
    None declared.