Editor—There are several problems with describing the electroclinical pattern in pyridoxine dependent seizures.1 One is defining the electrical features. Until now all published reports (including four of the five cases of Nabbout and colleagues) have described the electroencephalogram (EEG) in neonates who have received other anticonvulsants beforehand. It seems likely that anticonvulsants could affect the EEG, as suggested by the infant with the most pronounced burst suppression pattern in the paper of Nabbout and colleagues. The only other method of assessing the electrical pattern is on withdrawal, when we, like others, found that a continuous or intermittent high volt slow wave pattern with or without spikes was …