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Original article
Outcome of mother to infant acquired GBV-C/HGV infection
  1. G Zuina,
  2. B Saccania,
  3. S Di Giacomoa,
  4. E Tanzib,
  5. A R Zanettib,
  6. N Principia
  1. aFourth Paediatric Department, Università di Milano, Istituto di Scienze Biomediche Sacco, via GB Grassi 74, 20157 Milano, Italy, bInstitute of Virology University of Milan
  1. Dr Giovanna Zuin.

Abstract

Twelve children born to hepatitis C virus antibody GBV-C/HGV RNA positive mothers who acquired GBV-C/HGV infection by the vertical or perinatal route were studied. Most (91%) were persistently GBV-C/HGV RNA positive up to 12 months of age. Four out of six cases who acquired GBV-C/HGV alone had normal alanine amino transferase activities. Long lasting evidence of hepatocellular injury was detected only in children with GBV-C/HGV and hepatitis C virus and HIV coinfection.

  • hepatitis virus infection
  • mother to infant transmission
  • HIV

https://doi.org/10.1136/fn.80.1.F72

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