Pharmacokinetics and metabolism of rectally administered paracetamol in preterm neonates: Presented in part at the annual meeting of the European Society for Pediatric Research, Rotterdam, The Netherlands, July 3–6 1994.

R A van Lingen; J T Deinum; J M E Quak; A J Kuizenga; J G van Dam; K J S Anand; D Tibboel; A Okken

doi:10.1136/fn.80.1.F59

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Original article

Pharmacokinetics and metabolism of rectally administered paracetamol in preterm neonates

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	Abstract	Full	Pdf
May 2001	2	16	2
Jun 2001	1	25	2
Jul 2001	4	4	2
Aug 2001	4	7	3
Sep 2001	0	13	2
Oct 2001	0	13	4
Nov 2001	4	13	2
Dec 2001	1	17	5
Jan 2002	4	17	8
Feb 2002	2	23	4
Mar 2002	2	20	9
Apr 2002	0	12	6
May 2002	5	20	8
Jun 2002	4	19	2
Jul 2002	3	32	5
Aug 2002	2	8	3
Sep 2002	0	11	17
Oct 2002	1	14	2
Nov 2002	0	6	4
Dec 2002	3	12	8
Jan 2003	1	9	3
Feb 2003	10	15	7
Mar 2003	1	8	16
Apr 2003	1	9	3
May 2003	3	5	4
Jun 2003	0	14	8
Jul 2003	5	12	9
Aug 2003	6	19	9
Sep 2003	6	46	24
Oct 2003	8	17	13
Nov 2003	9	29	20
Dec 2003	9	26	14
Jan 2004	20	54	13
Feb 2004	17	70	17
Mar 2004	14	45	10
Apr 2004	9	30	3
May 2004	10	29	3
Jun 2004	10	18	16
Jul 2004	18	24	10
Aug 2004	14	22	7
Sep 2004	18	46	15
Oct 2004	15	17	10
Nov 2004	46	92	4
Dec 2004	86	56	8
Jan 2005	15	65	15
Feb 2005	21	65	7
Mar 2005	28	80	18
Apr 2005	8	39	17
May 2005	8	40	8
Jun 2005	12	29	16
Jul 2005	9	33	8
Aug 2005	4	30	13
Sep 2005	7	44	17
Oct 2005	15	59	14
Nov 2005	19	65	19
Dec 2005	38	43	21
Jan 2006	11	58	15
Feb 2006	12	44	18
Mar 2006	33	90	24
Apr 2006	14	53	20
May 2006	10	54	9
Jun 2006	9	24	6
Jul 2006	14	13	4
Aug 2006	8	25	8
Sep 2006	14	32	23
Oct 2006	23	51	27
Nov 2006	15	52	28
Dec 2006	11	34	9
Jan 2007	22	42	19
Feb 2007	15	29	17
Mar 2007	20	52	15
Apr 2007	33	14	11
May 2007	35	21	7
Jun 2007	16	10	3
Jul 2007	12	11	3
Aug 2007	20	14	9
Sep 2007	17	4	2
Oct 2007	13	10	12
Nov 2007	22	11	9
Dec 2007	13	6	3
Jan 2008	13	8	5
Feb 2008	34	22	8
Mar 2008	33	20	9
Apr 2008	28	11	4
May 2008	18	12	5
Jun 2008	29	9	6
Jul 2008	24	9	6
Aug 2008	23	13	1
Sep 2008	33	4	1
Oct 2008	27	3	4
Nov 2008	39	6	7
Dec 2008	32	4	5
Jan 2009	34	5	6
Feb 2009	22	7	1
Mar 2009	14	5	4
Apr 2009	9	2	2
May 2009	14	2	2
Jun 2009	24	1	3
Jul 2009	16	7	1
Aug 2009	27	1	3
Sep 2009	20	2	3
Oct 2009	19	8	2
Nov 2009	25	7	2
Dec 2009	20	2	1
Jan 2010	19	3	6
Feb 2010	14	3	0
Mar 2010	24	2	3
Apr 2010	6	3	4
May 2010	18	2	3
Jun 2010	19	8	4
Jul 2010	7	4	3
Aug 2010	3	7	4
Sep 2010	17	2	2
Oct 2010	22	2	7
Nov 2010	23	6	5
Dec 2010	5	8	1
Jan 2011	14	3	0
Feb 2011	17	1	0
Mar 2011	17	3	0
Apr 2011	26	1	3
May 2011	16	2	3
Jun 2011	17	4	3
Jul 2011	13	2	0
Aug 2011	16	4	3
Sep 2011	13	0	2
Oct 2011	16	2	0
Nov 2011	24	12	2
Dec 2011	14	29	8
Jan 2012	19	24	6
Feb 2012	13	22	7
Mar 2012	14	17	6
Apr 2012	24	49	10
May 2012	19	29	13
Jun 2012	17	38	8
Jul 2012	16	40	11
Aug 2012	12	37	9
Sep 2012	30	30	12
Oct 2012	42	37	14
Nov 2012	28	27	7
Dec 2012	15	27	4
Jan 2013	35	49	20
Feb 2013	41	40	16
Mar 2013	37	32	10
Apr 2013	48	44	11
May 2013	60	34	13
Jun 2013	18	15	9
Jul 2013	26	10	4
Aug 2013	8	16	4
Sep 2013	14	18	7
Oct 2013	22	17	7
Nov 2013	31	20	5
Dec 2013	23	25	11
Jan 2014	39	12	5
Feb 2014	17	15	7
Mar 2014	31	23	10
Apr 2014	20	24	11
May 2014	19	18	5
Jun 2014	21	21	5
Jul 2014	22	32	3
Aug 2014	14	27	8
Sep 2014	19	68	13
Oct 2014	23	61	17
Nov 2014	22	24	4
Dec 2014	10	16	5
Jan 2015	20	34	8
Feb 2015	23	15	4
Mar 2015	53	22	10
Apr 2015	28	16	10
May 2015	25	37	1
Jun 2015	15	18	4
Jul 2015	21	12	0
Aug 2015	10	13	4
Sep 2015	30	24	7
Oct 2015	14	4	3
Nov 2015	28	25	6
Dec 2015	49	11	21
Jan 2016	17	16	8
Feb 2016	30	18	9
Mar 2016	35	14	21
Apr 2016	23	16	7
May 2016	16	11	4
Jun 2016	15	7	4
Jul 2016	17	8	3
Aug 2016	15	8	2
Sep 2016	21	6	8
Oct 2016	24	15	4
Nov 2016	15	9	3
Dec 2016	21	21	5
Jan 2017	20	7	10
Feb 2017	20	12	3
Mar 2017	13	10	5
Apr 2017	9	14	5
May 2017	9	18	5
Jun 2017	11	17	2
Jul 2017	13	12	4
Aug 2017	19	13	0
Sep 2017	42	36	5
Oct 2017	36	25	5
Nov 2017	31	25	3
Dec 2017	36	18	3
Jan 2018	39	21	3
Feb 2018	42	18	2
Mar 2018	50	28	3
Apr 2018	72	38	9
May 2018	47	33	5
Jun 2018	21	21	8
Jul 2018	48	38	1
Aug 2018	47	23	9
Sep 2018	74	32	3
Oct 2018	94	44	17
Nov 2018	55	39	8
Dec 2018	46	26	5
Jan 2019	48	29	6
Feb 2019	47	34	4
Mar 2019	49	34	7
Apr 2019	78	63	7
May 2019	38	30	13
Jun 2019	59	38	9
Jul 2019	58	30	14
Aug 2019	70	32	4
Sep 2019	78	26	8
Oct 2019	75	33	5
Nov 2019	81	32	9
Dec 2019	83	33	10
Jan 2020	63	30	5
Feb 2020	60	53	9
Mar 2020	68	56	10
Apr 2020	42	35	17
May 2020	60	54	7
Jun 2020	43	25	12
Jul 2020	26	22	4
Aug 2020	18	18	6
Sep 2020	48	43	13
Oct 2020	49	43	9
Nov 2020	45	32	9
Dec 2020	46	40	13
Jan 2021	48	44	9
Feb 2021	39	31	6
Mar 2021	57	39	10
Apr 2021	38	34	12
May 2021	37	36	9
Jun 2021	32	32	2
Jul 2021	28	28	15
Aug 2021	26	26	14
Sep 2021	44	44	9
Oct 2021	47	37	30
Nov 2021	35	25	22
Dec 2021	40	23	15
Jan 2022	39	32	9
Feb 2022	44	40	6
Mar 2022	56	54	12
Apr 2022	41	33	10
May 2022	79	51	61
Jun 2022	50	41	11
Jul 2022	33	28	4
Aug 2022	76	50	34
Sep 2022	49	43	6
Oct 2022	49	43	15
Nov 2022	42	36	10
Dec 2022	39	38	3
Jan 2023	66	63	7
Feb 2023	78	73	7
Mar 2023	53	49	7
Apr 2023	63	44	9
May 2023	75	59	14
Jun 2023	34	34	7
Jul 2023	42	35	13
Aug 2023	46	37	12
Sep 2023	43	37	9
Oct 2023	37	32	8
Nov 2023	49	43	7
Dec 2023	70	14	6
Jan 2024	45	2	2
Feb 2024	69	4	1
Mar 2024	116	7	3
Total	7545	6915	2227

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