You are here

Article Text

Article menu
Download PDFPDF
Original article
In vitro effect of dexamethasone phosphate on hematopoietic progenitor cells in preterm infants
  1. Paola Papoff,
  2. Robert D Christensen,
  3. Jenny Harcum,
  4. Yan Li
  1. Department of Paediatrics, Division of Neonatology, University of Florida College of Medicine, P O Box 100296 Gainesville, FL, USA
  1. Dr Yai Li.

Abstract

The in vitro effect of dexamethasone on the clonal growth of haematopoietic progenitors in preterm infants was investigated. Concentrations of 106M to 109M were associated with a dose dependent inhibition of colony formation, with the most clinically important effects seen on the earliest erythroid and granulocyte-macrophage colonies. Because of the potential clinical implications of these observations, studies are needed to determine the effects of dexamethasone on haematopoiesis in preterm infants.

  • erythroid and granulocyte-macrophage colony formation
  • dexamethasone phosphate
  • erythropoietin

https://doi.org/10.1136/fn.78.1.F67

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes