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Does positive pressure ventilation increase arginine vasopressin in preterm neonates?
  1. Heather J Lamberta,
  2. Peter H Baylisb,
  3. Judith A McAulayb,
  4. Malcolm G Coulthardc
  1. aDepartment of Child Health, University of Newcastle upon Tyne, bDepartment of Medicine, cDepartment of Paediatric Nephrology, Royal Victoria Infirmary, Newcastle upon Tyne
  1. Dr H J Lambert Department of Child Health Royal Victoria Infirmary Newcastle upon Tyne NE1 4LP.


AIM To examine the effect of intermittent positive pressure ventilation (IPPV) on plasma arginine vasopressin concentration (pAVP) in preterm neonates.

METHODS Thirty five neonates were classified, at the time of blood sampling, into three groups: unstable ventilated; stable ventilated; and stable non-ventilated. A modification of an extraction method for pAVP was developed for use in studies on very small babies, and sampling methods were compared.

RESULTS The pAVP (median, range) was similar in the ventilated (1.85 pmol/l, 0.5 to 3.4) and non-ventilated (2.0, 0.5 to 2.6) stable babies, but was significantly higher (5.7, 1.1 to 25) in the unstable group. There was an inverse correlation between systolic blood pressure and pAVP concentration.

CONCLUSIONS This study shows that in preterm neonates pAVP concentration is affected by the clinical condition and blood pressure, but not by treatment with IPPV.

  • arginine vasopressin
  • assisted ventilation
  • systolic blood pressure
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