Article Text

Download PDFPDF
Hepatitis B vaccination in preterm infants
  1. Fu-Yuan Huang,
  2. Ping-Ing Lee,
  3. Chin-Yun Lee,
  4. Li-Min Huang,
  5. Luan-Yin Chang,
  6. Su-Chin Liu
  1. Department of Paediatrics, Mackay Memorial Hospital, Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan
  1. Dr Chin-Yun Lee, Department of Paediatrics, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan.


AIM To investigate the immunogenicity and safety of existing recommendations for hepatitis B vaccination in preterm infants.

METHODS Recombinant hepatitis B vaccine (H-B-VAX II, 5 μg per dose) was given to 85 preterm infants divided into two groups, using two different schedules. Forty four group A infants with birthweights of < 2000 g received three doses at 1, 2, and 7 months of age. Forty one group B infants with birthweights of ⩾2000 g received three doses at 0, 1, and 6 months of age.

RESULTS After vaccination, 42 infants from group A (95%) and 37 infants from group B (90%) developed protective levels of antibody. The final seropositive rate and the geometric mean concentration of hepatitis B surface antibody between the two groups were not significantly different. The immune response of preterm infants to hepatitis B vaccines was similar to that of term infants in a previous study.

CONCLUSIONS Preterm infants can be given hepatitis B vaccines using one of the above two different schedules, at a cutoff birthweight of 2000 g.

  • hepatitis B vaccine
  • prematurity
  • antibodies

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.