Article Text

Download PDFPDF
Neonatal symptomatic thromboembolism in Germany: two year survey


AIMS To determine the incidence of neonatal thromboembolism in Germany.

METHODS Diagnostic imaging techniques, therapeutic modalities, and short term outcome were evaluated in a prospective nationwide two year case registry study.

RESULTS The reported incidence of symptomatic neonatal thromboembolism, diagnosed in most cases with Doppler ultrasonography, was 5.1 per 100 000 births, with a total of 79 cases registered: renal venous thrombosis (n=35); venous thrombosis (n=25); and arterial vascular occlusion (n=19). Fifty seven of 79 thromboses were associated with additional risk factors (central line n=25, asphyxia n=13, septicaemia n=11, dehydration n=6, maternal diabetes n=2, cardiac disease n=1). Inherited thrombophilia was also diagnosed in seven out of 35 cases investigated. Twenty three children received supportive treatment: 42 received heparin and in 13 neonates thrombolytic agents were administered. Most neonates (91%) survived; seven died.

CONCLUSION Controlled multicentre studies are needed to obtain more information on treatment efficacy.

  • thromboembolism
  • Doppler ultrasonography
  • heparin
  • thrombolytic agents
  • Germany

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.