Article Text

Download PDFPDF
X-linked immune dysregulation, neonatal insulin dependent diabetes, and intractable diarrhoea.
  1. J. E. Peake,
  2. R. B. McCrossin,
  3. G. Byrne,
  4. R. Shepherd
  1. Royal Children's Hospital, Queensland, Australia.


    Four related male infants presented with neonatal diabetes mellitus, immune dysregulation with extremely high concentrations of immunoglobulin E, and intractable diarrhoea. They were all from one family, and all of them died. As far as is known this X-linked recessive disorder has not been described before. It is suggested that this is a new immunodeficiency in which type 2 T helper responses predominate.

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Linked Articles