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Reduction of pain response in premature infants using intraoral sucrose.
  1. L. A. Ramenghi,
  2. C. M. Wood,
  3. G. C. Griffith,
  4. M. I. Levene
  1. Division of Paediatrics and Child Health, University of Leeds School of Medicine.


    The potential of sucrose to reduce the pain response in a group of healthy premature infants was investigated. Fifteen infants of 32-34 weeks postmenstrual age were tested in a blind crossover manner on two separate occasions no more than two days apart. Either 1 ml of 25% sucrose solution or sterile water was syringed into the baby's mouth 2 minutes before routine heel lancing. Response to the painful stimuli was measured by duration of cry and by facial expression (pain score). There was a significant reduction in the duration of first cry, the percentage of time spent crying in the 5 minutes after heel prick, and the pain score in the sucrose treated group. It is concluded that sucrose has analgesic effects in healthy premature infants.

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